Science Heritage Journal | Galeri Warisan Sains (GWS)

Bridelia ferruguinea bark is investigated for its phytochemical composition and bioactivity to explore its therapeutic potential. The phytochemical analysis reveals significant quantities of alkaloids (62.95 mg/g), saponins (64.31 mg/g), flavonoids (100.19 mg/g), tannins (78.08 mg/g), and phenols (253.62 mg/g). The nitrogen-free extract dominates at 53.23%, followed by crude fiber at 24.44%. Additionally, the moisture, crude protein, crude fat, and ash content in Bridelia ferruguinea bark powder are reported at 7.63%, 2.15%, 8.72%, and 3.83%, respectively. Assessment of bioactivity indicates a lipid inhibition percentage of 23.88% and a vitamin C content of 55.97%. Moreover, the bark exhibits Fe chelation (13.44%) and DPPH radical scavenging activity (83.54%). Furthermore, it demonstrates inhibition of albumin denaturation (62.71%) and antiproteinase activity (69.534%). Importantly, it shows promising α-amylase inhibition (37.60%) and α-glucosidase inhibition (58.07%). These diverse bioactivities suggest potential applications in pharmaceuticals and nutraceuticals, warranting further studies for formulation development targeting both human and animal health. Bridelia ferruguinea bark emerges as a valuable natural resource with multifaceted therapeutic prospects, inviting extensive exploration for practical utilization.